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Mammalian Genotyping Service

Comprehensive human genetic maps

 

The following comprehensive human genetic linkage maps are based on CEPH family genotypes for short tandem repeat polymorphisms (microsatellites) generated primarily at three sites: in the Weber Laboratory at Marshfield, in Ray White's laboratory at the University of Utah, and at Généthon under the direction of Jean Weissenbach. In addition, we include many of the telomeric markers found in Rosenberg et al. (Genome Research 7:917-923, 1997).

Our linkage maps are most useful for determining which short tandem repeat polymorphisms are located within a particular chromosomal region of interest. Only data for CEPH families 1331, 1332, 1347, 1362, 1413, 1416, 884 and 102 were used (comprising 188 meioses), and thus the order of markers are not well determined. In particular, markers which are separated by little or no genetic distance generally have no recombination events separating them, and therefore are presented in arbitrary order. Additional ordering information for these markers can be obtained by consulting human physical maps (such as the Whitehead and the Stanford radiation hybrid maps; see Related Sites).

The data has been carefully screened for tight double recombination events (indicative of genotyping errors, mutations or gene conversions). Thus, the genetic distances are generally accurate, though because of the small numbers of meioses used, they are subject to large sampling errors.

We have identified numerous groups of markers which correspond to the same loci, though they have slightly different PCR primers. All but one marker from each group have been removed from the genetic maps. The Marker Information column contains links to tables which give the probe name, locus name, GenBank accession number, heterozygosity, allele size range and genotypes for CEPH individuals 1331-01 and 1331-02, for each marker. The Duplicate Markers column below contains links to tables which give the “cryptic” duplicate markers that were removed from the maps and the corresponding markers that were retained.

An “*” at the beginning of a line in the Genetic Maps or Marker Information indicates that the marker has a cryptic duplicate. An “x” at the beginning of a line in the Marker Information indicates that the marker is a cryptic duplicate and has been removed from the maps.

In the last row of the table, we give links to zip files containing the information for all of the chromosomes.

These maps are described in the following paper.

If you have any comments, questions, suggestions (other than to ask us to place additional markers on the map), or would like to report problems with these maps, please email Karl W. Broman (kbroman@jhsph.edu).

 

Chr. 1 Genetic Map Marker Information Duplicate Markers
Chr. 2 Genetic Map Marker Information Duplicate Markers
Chr. 3 Genetic Map Marker Information Duplicate Markers
Chr. 4 Genetic Map Marker Information Duplicate Markers
Chr. 5 Genetic Map Marker Information Duplicate Markers
Chr. 6 Genetic Map Marker Information Duplicate Markers
Chr. 7 Genetic Map Marker Information Duplicate Markers
Chr. 8 Genetic Map Marker Information Duplicate Markers
Chr. 9 Genetic Map Marker Information Duplicate Markers
Chr. 10 Genetic Map Marker Information Duplicate Markers
Chr. 11 Genetic Map Marker Information Duplicate Markers
Chr. 12 Genetic Map Marker Information Duplicate Markers
Chr. 13 Genetic Map Marker Information Duplicate Markers
Chr. 14 Genetic Map Marker Information Duplicate Markers
Chr. 15 Genetic Map Marker Information Duplicate Markers
Chr. 16 Genetic Map Marker Information Duplicate Markers
Chr. 17 Genetic Map Marker Information Duplicate Markers
Chr. 18 Genetic Map Marker Information Duplicate Markers
Chr. 19 Genetic Map Marker Information Duplicate Markers
Chr. 20 Genetic Map Marker Information Duplicate Markers
Chr. 21 Genetic Map Marker Information Duplicate Markers
Chr. 22 Genetic Map Marker Information Duplicate Markers
Chr. X Genetic Map Marker Information Duplicate Markers
Zip files Genetic Maps Marker Information Duplicate Markers